![]() Schistosomiasis, also known as bilharzia, is caused by blood flukes of the genus Schistosoma with approximately 240 million people infected. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: This work was supported by the grant P3 from Czech Science Foundation ( the project InterBioMed LO1302 from the Ministry of Education, Youth and Sports of the Czech Republic and by the institutional project RVO 61388963 ( LU was partially supported by the Sciex-NMS grant 11.222 from CRUS Switzerland. Received: JanuAccepted: Published: June 3, 2015Ĭopyright: © 2015 Fajtová et al. PLoS Negl Trop Dis 9(6):Įditor: Rodrigo Correa-Oliveira, René Rachou Research Center, BRAZIL (2015) Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. We conclude that SmPOP is important for parasite survival and may be a potential target for the development of anti-schistosomal drugs.Ĭitation: Fajtová P, Štefanić S, Hradilek M, Dvořák J, Vondrášek J, Jílková A, et al. Finally, we designed potent inhibitors of SmPOP that cause deleterious changes in cultured parasites. Interestingly, SmPOP, which is found in the tegument and parenchyma of the parasite, can cleave blood peptides involved in vasoregulation and we discuss how this ability may aid the parasite’s survival. We provide a comprehensive analysis of the peptidase’s expression, localization and functional biochemical properties. We, therefore, investigated prolyl oligopeptidase in Schistosoma mansoni (SmPOP) and found that it is expressed in those developmental stages that infect humans. Oligopeptidases from the S9 family are known virulence factors for protozoan trypanosomatids but have yet to be studied in parasitic flukes. Proteolytic enzymes are fundamental to the survival of parasites, and, hence, are attractive targets for drug intervention. Treatment and control of the disease relies on a single drug, and should resistance emerge, there would be increased pressure to discover new drug targets. Schistosomiasis (bilharzia) is a major global health problem caused by the schistosome flatworm which lives in the bloodstream. ![]()
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